Forschung Ostschweizer Kinderspital (FOKS)

Im Ostschweizer Kinderspital gehen klinischer Alltag und Forschung bereits seit vielen Jahren Hand in Hand. Klinische Studien auf hohem wissenschaftlichen Niveau helfen uns, die Erkrankungen des Kindesalters besser zu verstehen. So können wir unsere Behandlungsmethoden für die uns anvertrauten Kinder und Jugendlichen stetig verbessern und den bestmöglichen medizinischen Standard sicherstellen.

Unsere eigenen klinischen Studien basieren auf einer engen interdisziplinären Zusammenarbeit. Zudem nehmen wir auch an verschiedenen nationalen und internationalen Studien und Forschungsprojekten teil und sind gleichzeitig Mitglied in verschiedenen Forschungsnetzwerken wie zum Beispiel dem SwissPednet.

Nähere Informationen finden Sie in den nachfolgenden Rubriken.

Dr. med. Christian Kahlert

Leiter Forschungskommission
Facharzt für Kinder- und Jugendmedizin, Facharzt für Infektiologie

Studientitel Ansprechpartner

A Registry for Patients with Hereditary Thrombotic Thrombocytopenic Purpura (TTP)  (Upshaw-Schulman Syndrome)

Heinz Hengartner

Asphyxie-Register André Birkenmaier

Assessment of the cellular immunopathology in COVID-19 patients

Christian Kahlert

CARE Kinderstudie - Childhood, Allergy, Nutrition and Environment Roger Lauener

Chronic Critical Illness in Pediatric Intensive Care Unit in Switzerland - the OCToPuS Study

Bjarte Rogdo, Ellen Wild

Clinical and Laboratory Online Patient- and Research Database for Primary Immunodeficiencies in Switzerland Christian Kahlert
Cystic Fibrosis (CF) newborn screening Jürg Barben
Diagnosis of Tuberculosis in Swiss Children (CITRUS) Jürg Barben, Christian Kahlert

Diagnostische Bedeutung von Biomarkern in der Differentialdiagnose von Kindern mit einer ersten demyelinisierenden ZNS Erkrankung

Philip Broser

Diamond Blackfan Anämie in der Schweiz – Klinische und molekulargenetische Erfassung der betroffenen pädiatrischen Patienten

Heinz Hengartner

Die Bedeutung neurophysiologischer Methoden in der Abklärung neuropädiatrischer und neuromuskulärer Erkrankungen

Philip Broser

ECLip REGISTRY (European Consortium of Lopodystrophies)

Katrin Heldt

Effect of Allopurinol in addition to hypothermia for hypoxic-ischemic brain injury on neurocognitive outcome (ALBINO) André Birkenmaier
Einfluss Butyrat-reicher Ernährung auf die Symptome einer Nahrungsmittelallergie bei Kindern Caroline Roduit
Eingruppierung von Kindern und Jugendlichen mit Torsionsfehlstellungen im Hinblick auf Abweichungen im Gangbild und deren klinische Relevanz Harry Klima, Nathalie Alexander

Epidemiology of COVID-19 in Swiss PEDiatric population and their families (ECOPED)

Caroline Roduit, Christian Kahlert, Dagmar l`Allemand

ERNA - Ernährungsberatung bei Kindern mit Nahrungsmittelallergien (Dietary counselling of children with food allergy)

Caroline Roduit

ESNEK - Erhebung seltener neurologischer Erkrankungen im Kindesalter - Epidemiologie, Diagnose und klinisches Bild des Sturge-Weber-Syndroms und des PHACE Syndroms in Deutschland, der Schweiz und Österreich Philip Broser
European Cystic Fibrosis Society Patient Registry Jürg Barben

Evolution of blood cytokine profile, skin and stool microbiome in children with food allergies

Caroline Roduit

FamKom-Studie - Eine Qualitätskontrolle der Kommunikation

Gudrun Jäger

Frühe akustisch evozierte Potentiale als Prädiktor der späteren neurokognitiven Entwicklung bei Kindern

Philip Broser

Hospital-based surveillance of COVID-19, Influenza & Respiratory diseases in Switzerland

Anita Niederer-Loher

Identifizierung und Charakterisierung von Genveränderungen bei seltenen Epilepsie-Erkrankungen Oliver Maier

Induction and maintenance of immunity against varicella in pediatric orthotopic liver transplantation recipients: a retrospective and prospective nationwide study in Switzerland

Pascal Müller
Invasive Infections caused by Group A Streptococci (iGAS), Swiss Paediatric Surveillance Unit (SPSU) Anita Niederer-Loher

Investigating the influence of lower-limb torsional malalignment on children’s motion and joint loads

Nathalie Alexander

KIDS-STEP Studie - Eine randomisierte kontrollierte Studie zum zusätzlichen Einsatz von Kortison bei hospitalisierten Kindern mit ambulant erworbenen Infektionen der unteren Atemwege

Christian Kahlert

KIDS-STEP-MD - Eine Kohorten Studie über die Effekte von Antibiotika- und Steroidtherapie auf die Diversität des Mikrobioms der Atemwege

Christian Kahlert

Korrelation der neurologischen Untersuchung, des Ganglabors und der Sprunganalysedaten bei Patienten mit hereditären Neuropathien

Nathalie Alexander, Philip Broser

Magnesium-based, bioresorbable implants for pediatric elbow fractures, a single center pilot study for osteosynthesis with Magnezix screws in fractures of the Epicondylus ulnaris and Condylus radialis.

Thomas Krebs, Christoph Matissek

myKIDS-STEP - Studie ergänzend zur randomisierten kontrollierten KIDS-STEP Studie zur Verbesserung der Erregerdiagnostik bei der Lungenentzündung

Christian Kahlert

MDSi - Minimaler Datensatz der Schweizerischen Gesellschaft für Intensivmedizin SGI

Bjarte Rogdo

MoCHIV. Swiss Study of HIV Mother + Child Cohort (MoCHiV) aims to collect data on the pregnancy and delivery of HIV-infected women as well as on the physical development of uninfected children - born to HIV-positive mothers - up to their entrance to school. It identifies the side effects and long-term effects of new drugs and treatments Christian Kahlert
NEC-Register - SWISS NECROTIZING ENTEROCOLITIS REGISTRY - A retrospective and prospective observational trial in neonates with Necrotizing Enterocolitis Julia Rheinberger

Outcome of very preterm infants after grade III intraventricular haemorrhage, periventricular haemorrhagic infarction or cystic periventricular leukomalacia (OPTION Study)

Bjarte Rogdo

PathMate2: The Impact of Health Information System Services on the Effects of Therapy in Overweight Teenagers Dagmar l`Allemand

Retrospektive longitudinale Analyse von klinischen und laborchemischen Daten in Abhängigkeit von medikamentöser
Therapie bei pädiatrischen Patienten mit Schilddrüsenerkrankungen: Erstellung einer Datenbank zur Algorithmen-Entwicklung zur optimierten Dosisfindung im Neugeborenen-, Kindes- und Jugendaltervia pharmakologische Modellierrung

Dagmar l`Allemand

Schweizerisches NeuroPädiatrisches Schlaganfall-Register (SNPSR) Oliver Meier

Seroconversion for SARS-CoV-2 among co-workers of a children’s hospital

Christian Kahlert

SHCS810 - Severe Infections and Haematological and Immunological Abnormalities in HIV Exposed Uninfected Children in Switzerland Christian Kahlert

Single-Fibre EMG Analysis of the maturation of the neuromuscular endplate during reinnervation after traumatic nerve injury

Philip Broser
SMILE: Strategy for Maintenance of HIV suppression with once daiLy Integrase inhibitor +darunavir/ritonavir in children Christian Kahlert
Swiss Autoimmune Hepatitis Cohort Study (SASL38) Pascal Müller
Swiss Cerebralpalsy Registry (Swiss-CP-Reg) Christoph Künzle
Swiss Cohort of Persons with Disorders of Sex Development (iDSD) Dagmar l`Allemand

Swiss Hemophilia Registry

Heinz Hengartner

Swiss Inflammatory Bowel Disease Cohort Study (SIBDCS) George Marx
Swiss Pediatric Airway Cohort (SPAC) Jürg Barben
Swiss Primary Sclerosing Cholangitis Cohort Study (SASL40) Pascal Müller
Swissnoso – Swiss national registry for the surveillance of postoperative wound infections Christian Kahlert

The EPICENTRE (ESPNIC Covid pEdiatric Neonatal Registry) initiative. A multidisciplinary initiative for an international SARS-CoV-2 infections registry

Bjarte Rogdo

The Incidence of and Risk Factors for Coronavirus Disease 2019 (COVID-19) among Healthcare Workers - a Prospective Cohort Study - Amendment/Extension: Coronavirus Disease 2019 (COVID-19) bei Mitarbeitenden in systemrelevanten Berufen

Christian Kahlert

The susceptibility to other infectious disease following measles during a three year observation period - A case control study

Anita Niederer-Loher

Wirksamkeit von rezeptierten Orthesen bei Kindern mit Zerebralparese

Nathalie Alexander

Darüber hinaus sind wir Mitglied der Schweizerischen Pädiatrischen Onkologie Gruppe (SPOG). Diese ist eine gemeinnützige Organisation, welche sich durch patientenorientierte Krebsforschung für verbesserte Behandlungsmöglichkeiten und höhere Lebensqualität an Krebs erkrankter Kinder und Jugendlicher einsetzt.

Ausserdem erheben wir Daten für das nationale Schweizer Kinderkrebsregister. Dieses erfasst Neuerkrankungen, dokumentiert die Behandlung und beinhaltet Langzeituntersuchungen.

Ansprechpartner am Ostschweizer Kinderspital sind:
Jeanette Greiner-Lang und Heinz Hengartner

1: Alexander N, Strutzenberger G, Schwameder H. The use of the gradual yielding mechanism during downhill walking in persons with transfemoral amputation – a case study. Journal of Prosthetics and Orthotics. 2020;2020(3):203-211.

2: Appert O, Garcia AR, Frei R, Roduit C, et al. Initial butyrate producers during infant gut microbiota development are endospore formers. Environmental Microbiology. 2020;22(9):3909-3921. doi:https://doi.org/10.1111/1462-2920.15167

3: Barben J. First description of cystic fibrosis. Journal of Cystic Fibrosis. 2021;20(1):183. doi:10.1016/j.jcf.2020.08.008

4: Barben J, Castellani C, Munck A, et al. Updated guidance on the management of children with cystic fibrosis transmembrane conductance regulator-related metabolic syndrome/cystic fibrosis screen positive, inconclusive diagnosis (CRMS/CFSPID). Journal of Cystic Fibrosis. Published online November 27, 2020. doi:10.1016/j.jcf.2020.11.006

5: Barben J, Chudleigh J. Processing Newborn Bloodspot Screening Results for CF. Int J Neonatal Screen. 2020;6(2):25. doi:10.3390/ijns6020025

6: Barben J, Southern KW. Why Do We Screen Newborn Infants for Cystic Fibrosis? Int J Neonatal Screen. 2020;6(3):56. doi:10.3390/ijns6030056

7: Baron RC, Risch L, Weber M, Kahlert CR, et al. Frequency of serological non-responders and false-negative RT-PCR results in SARS-CoV-2 testing: a population-based study. Clinical Chemistry and Laboratory Medicine (CCLM). 2020;58(12):2131-2140. doi:10.1515/cclm-2020-0978

8: Bieber T, Traidl-Hoffmann C, Schäppi G, Lauener R, Akdis C, Schmid-Grendlmeier P. Unraveling the complexity of atopic dermatitis: The CK-CARE approach toward precision medicine. Allergy. 2020;75(11):2936-2938. doi:10.1111/all.14194

9: Borghesi A, Trück J, Asgari S, Kahlert CR, Niederer-Loher A, et al. Whole-exome Sequencing for the Identification of Rare Variants in Primary Immunodeficiency Genes in Children With Sepsis: A Prospective, Population-based Cohort Study. Clinical Infectious Diseases. 2020;71(10):e614-e623. doi:10.1093/cid/ciaa290

10: Broser PJ, Middelmann T, Sometti D, Braun C. Optically pumped magnetometers disclose magnetic field components of the muscular action potential. J Electromyogr Kinesiol. 2021;56:102490. doi:10.1016/j.jelekin.2020.102490

12: Buettcher M, Trueck J, Niederer-Loher A, Kahlert CR, et al. Correction to: Swiss consensus recommendations on urinary tract infections in children. Eur J Pediatr. 2021;180(3):675-677. doi:10.1007/s00431-020-03820-3

13: Buettcher M, Trueck J, Niederer-Loher A, Kahlert CR, et al. Swiss consensus recommendations on urinary tract infections in children. Eur J Pediatr. 2021;180(3):663-674. doi:10.1007/s00431-020-03714-4

14: Depner M, Taft DH, Kirjavainen PV, Roduit C, Lauener R, et al. Maturation of the gut microbiome during the first year of life contributes to the protective farm effect on childhood asthma. Nature Medicine. 2020;26(11):1766-1775. doi:10.1038/s41591-020-1095-x

15: Döring JH, Saffari A, Bast T, Broser PJ, Maier O, et al. The Phenotypic Spectrum of PRRT2-Associated Paroxysmal Neurologic Disorders in Childhood. Biomedicines. 2020;8(11):456. doi:10.3390/biomedicines8110456

16: Greiter BM, Kahlert CR, Eberhard N, et al. Lymphocyte Subsets in HIV-Exposed Uninfected Infants: The Impact of Neonatal Postexposure Prophylaxis With Zidovudine. Open Forum Infectious Diseases. 2020;7(ofaa108). doi:10.1093/ofid/ofaa108

17:  Haecker F-M, Hebra A, Ferro MM. Pectus bar removal – why, when, where and how. Journal of Pediatric Surgery. 2021;56(3):540-544. doi:10.1016/j.jpedsurg.2020.11.001

18: Hengartner T, Adams M, Pfister RE, Rogdo B, et al. Associations between Red Blood Cell and Platelet Transfusions and Retinopathy of Prematurity. Neonatology. Published online December 8, 2020:1-7. doi:10.1159/000512020

19: Kahlert CR, Cipriani M, Vernazza P. Novel dual HIV maintenance therapy with nevirapine plus lamivudine retain viral suppression through 144 weeks – A proof-of-concept study. PLOS ONE. 2020;15(9):e0237770. doi:10.1371/journal.pone.0237770

20: Kahlert CR, Persi R, Güsewell S, et al. Non-occupational and occupational factors associated with specific SARS-CoV-2 antibodies among Hospital Workers – a multicentre cross-sectional study. medRxiv. Published online December 13, 2020:2020.11.10.20229005. doi:10.1101/2020.11.10.20229005

21: Kohler PP, Kahlert CR, Sumer J, et al. Prevalence of SARS-CoV-2 antibodies among Swiss hospital workers: Results of a prospective cohort study. Infection Control & Hospital Epidemiology. Published online undefined/ed:1-5. doi:10.1017/ice.2020.1244

22: Kohns Vasconcelos M, Meyer Sauteur PM, Santoro R, Wachinger T, et al. Randomised placebo-controlled multicentre effectiveness trial of adjunct betamethasone therapy in hospitalised children with community-acquired pneumonia: a trial protocol for the KIDS-STEP trial. BMJ Open. 2020;10(12):e041937. doi:10.1136/bmjopen-2020-041937

23: Kovac M, Risch L, Thiel S, Kahlert CR, et al. EDTA-Anticoagulated Whole Blood for SARS-CoV-2 Antibody Testing by Electrochemiluminescence Immunoassay (ECLIA) and Enzyme-Linked Immunosorbent Assay (ELISA). Diagnostics. 2020;10(8):593. doi:10.3390/diagnostics10080593

24: Kremer Hovinga JA, Braschler TR, Buchkremer F, Hengartner H, et al. Insights from the Hereditary Thrombotic Thrombocytopenic Purpura Registry: Discussion of Key Findings Based on Individual Cases from Switzerland. Hamostaseologie. 2020;40(S 01):S5-S14. doi:10.1055/a-1282-2264

25: Pillai N, Lupatsch JE, Dusheiko M, Marx G, et al. Evaluating the Cost-Effectiveness of Early Compared with Late or No Biologic Treatment to Manage Crohn’s Disease using Real-World Data. J Crohns Colitis. 2020;14(4):490-500. doi:10.1093/ecco-jcc/jjz169

26: Risch M, Weber M, Thiel S, Kahlert CR, et al. Temporal Course of SARS-CoV-2 Antibody Positivity in Patients with COVID-19 following the First Clinical Presentation. BioMed Research International. 2020;2020:e9878453. doi:10.1155/2020/9878453

27: Roth JA, Radevski G, Marzolini C, Kahlert CR, et al. Cohort-Derived Machine Learning Models for Individual Prediction of Chronic Kidney Disease in People Living With Human Immunodeficiency Virus: A Prospective Multicenter Cohort Study. The Journal of Infectious Diseases. 2020;(jiaa236). doi:10.1093/infdis/jiaa236

28: Schaffner A, Risch L, Aeschbacher S, Kahlert CR, et al. Characterization of a Pan-Immunoglobulin Assay Quantifying Antibodies Directed against the Receptor Binding Domain of the SARS-CoV-2 S1-Subunit of the Spike Protein: A Population-Based Study. Journal of Clinical Medicine. 2020;9(12):3989. doi:10.3390/jcm9123989

29: Shenker N, Aprigio J, Arslanoglu S, Malzacher A, et al. Maintaining safety and service provision in human milk banking: a call to action in response to the COVID-19 pandemic. The Lancet Child & Adolescent Health. 2020;4(7):484-485. doi:10.1016/S2352-4642(20)30134-6

30: Streuli JC, Anderson J, Alef-Defoe S, et al. Combining the best interest standard with shared decision-making in paediatrics—introducing the shared optimum approach based on a qualitative study. Eur J Pediatr. 2021;180(3):759-766. doi:10.1007/s00431-020-03756-8

31: Thiel SL, Weber MC, Risch L, Kahlert CR, et al. Flattening the curve in 52 days: characterisation of the COVID-19 pandemic in the Principality of Liechtenstein – an observational study. Swiss Medical Weekly. 2020;150(4142). doi:10.4414/smw.2020.20361

32: Venter C, Greenhawt M, Meyer RW, Roduit C, et al. EAACI position paper on diet diversity in pregnancy, infancy and childhood: Novel concepts and implications for studies in allergy and asthma. Allergy. 2020;75(3):497-523. doi:10.1111/all.14051

33: West EA, Anker D, Amati R, Kahlert CR, et al. Corona Immunitas: study protocol of a nationwide program of SARS-CoV-2 seroprevalence and seroepidemiologic studies in Switzerland. Int J Public Health. 2020;65(9):1529-1548. doi:10.1007/s00038-020-01494-0

34: Müller P, Rose K, Hayer A, Petit L-M, Laimbacher J. Handlungsanweisungen vegetarische und vegane Ernährung im Säuglings- und Kleinkindesalter. pädiatrie schweiz. Published February 19, 2020. https://www.paediatrieschweiz.ch/handlungsanweisungen-vegetarische-vegane-ernaehrung/

35: Spalinger J, Müller P. Eosinophile gastrointestinale Erkrankungen. pädiatrie schweiz. Published July 1, 2020. Accessed April 7, 2021. https://www.paediatrieschweiz.ch/eosinophile-gastrointestinale-erkrankungen/

36: Müller B, Müller P. Zuckerkonsum bei Kindern und Jugendlichen, Status Quo und Empfehlungen. pädiatrie schweiz. Published July 1, 2020. Accessed April 7, 2021. https://www.paediatrieschweiz.ch/zuckerkonsum-kinder-jugendlichen-status-quo-und-empfehlungen/

37: Hengartner H, von der Weid N, Mattiello V, Schmugge Liner M, Renella R. Diagnose und Behandlung von Eisenmangel bei Kindern mit oder ohne Anämie: Zusammenfassung der Konsensempfehlungen der SPOG-Arbeitsgruppe Pädiatrische Hämatologie. pädiatrie schweiz. Published December 21, 2020. Accessed April 7, 2021. https://www.paediatrieschweiz.ch/diagnose-und-behandlung-von-eisenmangel-bei-kindern-mit-oder-ohne-anamie/

38: Alexander N, Wegener R, Lengnick H, Payne E, Klima H, Cip J, Studer K. Compensatory gait deviations in patients with increased outward tibial torsion pre and post tibial derotation osteotomy. - Abstract - Europe PMC. Accessed April 7, 2021. https://europepmc.org/article/med/31981934

39: Barben J, Southern K. Newborn Screening for Cystic Fibrosis. Accessed April 7, 2021. https://www.mdpi.com/books/pdfview/book/2841

40: Broser PJ, Middelmann T, Sometti D, Braun C. Optically pumped magnetometers disclose magnetic field components of the muscular action potential - ScienceDirect. Accessed March 17, 2021. https://www.sciencedirect.com/science/article/abs/pii/S1050641120301322?via%3Dihub

41: Hasan AO, Bomze D, Risch L, Kahlert CR, et al. Severe COVID-19 is associated with elevated serum IgA and antiphospholipid IgA-antibodies. - Abstract - Europe PMC. https://europepmc.org/article/PMC/7543315

42: Cernoch PS, Fournier N, Zeitz J, Marx G, et al. Lower Risk of B1-to-pB3-Stage Migration in Crohn’s Disease Upon Immunosuppressive and Anti-TNF Treatment in the Swiss IBD Cohort Study. Dig Dis Sci. 2020;65(9):2654-2663. doi:10.1007/s10620-019-05978-9

43: de Jong CCM, Pedersen ESL, Mozun R, Barben J, et al. A clinically significant bronchodilator response in children: how should it be measured? Eur Respir J. 2020;55(5). doi:10.1183/13993003.00636-2020

44: Disse SC, Toelle SP, Schroeder S, Broser PJ, et al. Epidemiology, Clinical Features, and Use of Early Supportive Measures in PHACE Syndrome: A European Multinational Observational Study. Neuroepidemiology. 2020;54(5):383-391. doi:10.1159/000508187

45: Frühwald MC, Hasselblatt M, Nemes K, Hengartner H, et al. Age and DNA methylation subgroup as potential independent risk factors for treatment stratification in children with atypical teratoid/rhabdoid tumors. Neuro Oncol. 2020;22(7):1006-1017. doi:10.1093/neuonc/noz244

46: Heckmann J, Todorova M, Müller S, Broser PJ, Sturm V. First Clinical Experience with Anti-myelin Oligodendrocyte Glycoprotein Antibody-Positive Optic Neuritis. Klin Monbl Augenheilkd. 2020;237(4):458-463. doi:10.1055/a-1068-2506

47: Jenny C, Lütschg J, Broser PJ. Change in cross-sectional area of the median nerve with age in neonates, infants and children analyzed by high-resolution ultrasound imaging. Eur J Paediatr Neurol. 2020;29:137-143. doi:10.1016/j.ejpn.2020.07.017

48: Mattiello V, Schmugge M, Hengartner H, von der Weid N, Renella R, SPOG Pediatric Hematology Working Group. Diagnosis and management of iron deficiency in children with or without anemia: consensus recommendations of the SPOG Pediatric Hematology Working Group. Eur J Pediatr. 2020;179(4):527-545. doi:10.1007/s00431-020-03597-5

49: Müller P. Vegan Diet in Young Children. Nestle Nutr Inst Workshop Ser. 2020;93:103-110. doi:10.1159/000503348

50: Venter C, Agostoni C, Arshad SH, Roduit C, et al. Dietary factors during pregnancy and atopic outcomes in childhood: A systematic review from the European Academy of Allergy and Clinical Immunology. Pediatr Allergy Immunol. 2020;31(8):889-912. doi:10.1111/pai.13303

51: Wagner N, Crisinel P-A, Kahlert CR, Martinez De Tejada B. [Breastfeeding for HIV-positive mothers in Switzerland : are we ready to discuss ?]. Rev Med Suisse. 2020;16(712):2050-2054.

52: Wiedemann A, Pastore-Wapp M, Slavova N, Maier O, et al. Impact of stroke volume on motor outcome in neonatal arterial ischemic stroke. Eur J Paediatr Neurol. 2020;25:97-105. doi:10.1016/j.ejpn.2019.10.006

53: Zdravkovic V, Alexander N, Wegener R, Spross C, Jost B. How Do Scapulothoracic Kinematics During Shoulder Elevation Differ Between Adults With and Without Rotator Cuff Arthropathy? Clin Orthop Relat Res. 2020;478(11):2640-2649. doi:10.1097/CORR.0000000000001406

54: Zuniga-Villanueva G, Widger K, Medeiros C, Trenholm M, Streuli JC. Specialized Pediatric Palliative Care in Neonates with Life-Limiting Illness: A Systematic Review. Am J Perinatol. Published online April 24, 2020. doi:10.1055/s-0040-1710031

55: Müller P, Bärlocher K. Normale Ernährung von Neugeborenen und Säuglingen – Umsetzung in der Schweiz. Buchkapitel in Pädiatrie - Grundlagen und Praxis (Springer Reference Medizin), Hofmann G.F.F. et al.; 5. Auflage. ISBN 978-3-662-60300-0

56: Cip J, Lengnick H. 12/m – starke Reduktion der Gehfähigkeit nach Trampolinsprüngen. Der Orthopäde. Published online October 9, 2020. doi:10.1007/s00132-020-04011-6

1: Vidal I, Wildhaber BE, Moehrlen U, Regamey N, Trachsel D, Cholewa D, Barben J, u. a. A Swiss database and biobank to better understand and manage congenital lung anomalies. Swiss Medical Weekly [Internet]. 30. Juni 2019;149(2526). Verfügbar unter: https://smw.ch/article/doi/smw.2019.20081

2: Metzler S, Frei R, Schmaußer‐Hechfellner E, Mutius E von, Pekkanen J, Karvonen AM, Lauener R, Roduit C, u. a. Association between antibiotic treatment during pregnancy and infancy and the development of allergic diseases. Pediatric Allergy and Immunology. 2019;30(4):423–33.

3: Rueegg CS, Kuehni CE, Gallati S, Jurca M, Jung A, Casaulta C, Barben J, u. a. Comparison of two sweat test systems for the diagnosis of cystic fibrosis in newborns. Pediatr Pulmonol. 2019;54(3):264–72.

4: Broser P, Die Bedeutung neurophysiologischer Methoden in der Abklärung neuropädiatrischer und neuromuskulärer Erkrankungen [Internet]. springermedizin.de. Verfügbar unter: https://www.springermedizin.de/die-bedeutung-neurophysiologischer-methoden-in-der-abklaerung-ne/17509140

5: de Jong CCM, Pedersen ES, Goutaki M, Trachsel D, Barben J, Kuehni CE. Do clinical investigations predict long-term wheeze? A follow-up of pediatric respiratory outpatients. Pediatr Pulmonol. 2019;54(8):1156–61.

6: Frei R, Roduit C, Ferstl R, O’Mahony L, Lauener RP. Exposure of Children to Rural Lifestyle Factors Associated With Protection Against Allergies Induces an Anti-Neu5Gc Antibody Response. Front Immunol [Internet]. 16. Juli 2019;10. Verfügbar unter: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660244/

7: Barben J, Schuurmans MM, Zürcher A, Kaelin RM, Schmid T, Stambach D, u. a. Harm reduction – keine wirksame Strategie zur Tabakbekämpfung. Schweizerische Ärztezeitung. 31. Juli 2019;100(3132):1041–4.

8: Roduit C, Frei R, Ferstl R, Loeliger S, Westermann P, Rhyner C, u. a. High levels of butyrate and propionate in early life are associated with protection against atopy. Allergy. 2019;74(4):799–809.

9: Wenskus J, Burmester G, Staude C, Krebs T, Reinshagen K. Ileumpouch bei Patienten mit Zuelzer-Wilson-Syndrom – Bedeutung für die Patienten? Monatsschr Kinderheilkd [Internet]. 28. Januar 2019; Verfügbar unter: https://doi.org/10.1007/s00112-019-0646-z

10: Southern KW, Barben J, Gartner S, Munck A, Castellani C, Mayell SJ, u. a. Inconclusive diagnosis after a positive newborn bloodspot screening result for cystic fibrosis; clarification of the harmonised international definition. Journal of Cystic Fibrosis. 1. November 2019;18(6):778–80.

11: Trinler U, Schwameder H, Baker R, Alexander N. Muscle force estimation in clinical gait analysis using AnyBody and OpenSim. J Biomech. 27 2019;86:55–63.

12: Possner M, Buechel RR, Vontobel J, Mikulicic F, Gräni C, Benz DC, Stambach D, u. a. Myocardial blood flow and cardiac sympathetic innervation in young adults late after arterial switch operation for transposition of the great arteries. Int J Cardiol. 15 2020;299:110–5.

13: Kasteler R, Belle F, Schindera C, Barben J, Gumy-Pause F, Tinner EM, u. a. Prevalence and reasons for smoking in adolescent Swiss childhood cancer survivors. Pediatr Blood Cancer. 2019;66(1):e27438.

14: Barben J, Künzli N. Tabakprävention angesichts neuer Trends. Swiss Medical Forum. 14. August 2019;19(3334):531–6.

15: Alexander N, Studer K, Lengnick H, Payne E, Klima H, Wegener R. The impact of increased femoral antetorsion on gait deviations in healthy adolescents. J Biomech. 27 2019;86:167–74.

16: Johannes J, Greutmann M, Tobler D, Bouchardy J, Stambach D, Wustmann K, u. a. The impact of trisomy 21 on treatment modalities and outcome in adults with congenital heart disease in Switzerland. Pulm Circ. März 2019;9(1):2045894018811147.

17: Nicklaus S, Divaret-Chauveau A, Chardon M-L, Roduit C, Kaulek V, Ksiazek E, u. a. The protective effect of cheese consumption at 18 months on allergic diseases in the first 6 years. Allergy. 2019;74(4):788–98.

18: Philip J. Broser, Jürg Lütschg, Elektroneurografische und elektromyografische Diagnostik in der Neuropädiatrie Thieme E-Journals - Klinische Neurophysiologie / Abstract [Internet]. Verfügbar unter: www.thieme-connect.com/products/ejournals/abstract/10.1055/a-0993-6459

19: Petit L-M, Nydegger A, Müller P. [Vegan diet in children : what potential deficits to monitor ?]. Rev Med Suisse. 13. Februar 2019;15(638):373–5.

20: Behrend H, Lengnick H, Zdravkovic V, Ladurner A, Rudin D, Erschbamer M, u. a. Vitamin C demand is increased after total knee arthroplasty: a double-blind placebo-controlled-randomized study. Knee Surg Sports Traumatol Arthrosc. April 2019;27(4):1182–8.

21: Fulchini R, Albrich WC, Kronenberg A, Egli A, Kahlert CR, Schlegel M, u. a. Antibiotic-resistant pathogens in different patient settings and identification of surveillance gaps in Switzerland – a systematic review. Epidemiology & Infection [Internet]. ed 2019;147. Verfügbar unter: www.cambridge.org/core/journals/epidemiology-and-infection/article/antibioticresistant-pathogens-in-different-patient-settings-and-identification-of-surveillance-gaps-in-switzerland-a-systematic-review/8C262E379A2A3CCF53D977DDFED25ADD

22: Asner SA, Agyeman PKA, Gradoux E, Posfay-Barbe KM, Heininger U, Giannoni E, Kahlert CR, u. a. Burden of Streptococcus pneumoniae Sepsis in Children After Introduction of Pneumococcal Conjugate Vaccines: A Prospective Population-based Cohort Study. Clin Infect Dis. 15. Oktober 2019;69(9):1574–80.

23: (Kahlert CR). European Pregnancy and Paediatric HIV Cohort Collaboration (EPPICC) Study Group in EuroCoord. CD4 recovery following antiretroviral treatment interruptions in children and adolescents with HIV infection in Europe and Thailand. HIV Med. 2019;20(7):456–72.

24: (Kahlert CR). SDHA gain-of-function engages inflammatory mitochondrial retrograde signaling via KEAP1-Nrf2. - PubMed - NCBI [Internet]. Verfügbar unter: www.ncbi.nlm.nih.gov/pubmed/31527833

25: (Kahlert CR). Swiss Medical Weekly - Nevirapine in HIV maintenance therapy – can “old drugs” survive in current HIV management? [Internet].. Verfügbar unter: smw.ch/article/doi/smw.2019.20053

26: Compagno F, Naegele K, Kahlert CR, Hösli I, Aebi-Popp K, Martinez de Tejada B, u. a. The rate of mother-to-child transmission of antiretroviral drug-resistant HIV strains is low in the Swiss Mother and Child HIV Cohort Study. Swiss Med Wkly. 25. März 2019;149:w20059.

27: Rumping L, Büttner B, Maier O, Rehmann H, Lequin M, Schlump J-U, u. a. Identification of a Loss-of-Function Mutation in the Context of Glutaminase Deficiency and Neonatal Epileptic Encephalopathy. JAMA Neurol. 1. März 2019;76(3):342–50.

28: Chudleigh J, Ren CL, Barben J, Southern KW. International approaches for delivery of positive newborn bloodspot screening results for CF. J Cyst Fibros. 2019;18:614-21

29: De Jong C, Pedersen E,  Mozun R; Goutaki M, Trachsel D, Barben J, Kuehni CE. Diagnosis of asthma in children: the contribution of a detailed history and test results. Eur Respir J 2019, Dec 4;54(6). pii: 1901326.

30: Bildstein T, Maschler I, Baumgartner G, Rauch S, Waibel P, Barben J. Ungewöhnliche Präsentation eines Lipoms im Kindesalter. Swiss Medical Forum 2019; 19:624–6

31: Barben J. Lungenfachgesellschaften warnen vor E-Zigaretten. info@onkologie 2019;5:13-16

32: Barben J. Snus, Shisha und E-Zigaretten – Tabakprävention angesichts neuer Produkte. Kinderärzte Schweiz, Januar 2019

33: Brauchli P, Coullery P, Barben J. Regulierung von Tabak- und Nikotinprodukten - Grundsätze des Heilmittelrechts sind anzuwenden. Schweizerische Ärztezeitung 2019;100:1765–7

34: Haecker F-M, Krebs T, Kocher GJ, Schmid RA, Sesia SB. Sternal elevation techniques during the minimally invasive repair of pectus excavatum.Interact Cardiovasc Thorac Surg. 2019;29(4):497-502. doi:10.1093/icvts/ivz142

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Identification of a Loss-of-Function Mutation in the Context of Glutaminase
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2: Schöb M, Müller P, Gerth Y, Korte W, Rickli H, Brändle M, Bärlocher A, Bilz S. [Diagnosis and Treatment of Familial Hypercholesterolemia]. Praxis (Bern 1994).
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3: Nicklaus S, Divaret-Chauveau A, Chardon ML, Roduit C, Kaulek V, Ksiazek E, Dalphin ML, Karvonen AM, Kirjavainen P, Pekkanen J, Lauener R, Schmausser-Hechfellner E, Renz H, Braun-Fahrländer C, Riedler J, Vuitton DA, Mutius EV, Dalphin JC; Pasture Study Group.
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4: Sesia SB, Heitzelmann M, Schaedelin S, Magerkurth O, Kocher GJ, Schmid RA, Haecker FM.
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5: Greiner J, Schrappe M, Claviez A, Zimmermann M, Niemeyer C, Kolb R, Eberl W, Berthold F, Bergsträsser E, Gnekow A, Lassay E, Vorwerk P, Lauten M, Sauerbrey A, Rischewski J, Beilken A, Henze G, Korte W, Möricke A.
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6: Kasteler R, Belle F, Schindera C, Barben J, Gumy-Pause F, Tinner EM, Kuehni CE; Swiss Pediatric Oncology Group (SPOG).
Prevalence and reasons for smoking in adolescent Swiss childhood cancer survivors. Pediatr Blood Cancer. 2019 Jan;66(1):e27438.
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7: Alexander N, Wegener R, Zdravkovic V, North D, Gawliczek T, Jost B.
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2018 Oct;66:267-272. doi: 10.1016/j.gaitpost.2018.09.008. Epub 2018 Sep 10. PubMed PMID: 30223210.

8: Gerull R, Brauer V, Bassler D, Laubscher B, Pfister RE, Nelle M, Müller B, Roth-Kleiner M, Gerth-Kahlert C, Adams M; Swiss Neonatal Network & Follow-up Group.
Prediction of ROP Treatment and Evaluation of Screening Criteria in VLBW Infants-a Population Based Analysis.
Pediatr Res. 2018 Nov;84(5):632-638. doi: 10.1038/s41390-018-0128-3. Epub 2018 Aug 6. PubMed PMID: 30188497.

9: Dierig A, Berger C, Agyeman PKA, Bernhard-Stirnemann S, Giannoni E, Stocker M, Posfay-Barbe KM, Niederer-Loher A, Kahlert CR, Donas A, Hasters P, Relly C, Riedel T, Aebi C, Schlapbach LJ, Heininger U; Swiss Pediatric Sepsis Study.
Time-to-Positivity of Blood Cultures in Children With Sepsis. Front Pediatr. 2018 Aug 8;6:222. doi: 10.3389/fped.2018.00222.
eCollection 2018. PubMed PMID: 30135859; PubMed Central PMCID: PMC6092514.

10: Farowski F, Els G, Tsakmaklis A, Higgins PG, Kahlert CR, Stein-Thoeringer CK, Bobardt JS, Dettmer-Wilde K, Oefner PJ, Vehreschild JJ, Vehreschild MJGT.
Assessment of urinary 3-indoxyl sulfate as a marker for gut microbiota diversity and abundance of Clostridiales. Gut Microbes. 2018 Aug 17:1-9. doi: 10.1080/19490976.2018.1502536. [Epub ahead of print] PubMed PMID: 30118620.

11: Häcker FM. Nonsurgical Treatment of Chest Wall Deformities: Contradiction or Complement? Eur J Pediatr Surg. 2018 Aug;28(4):369-372.
doi: 10.1055/s-0038-1668128. Epub 2018 Aug 13. Review. PubMed PMID: 30103239.

12: Gilles S, Akdis C, Lauener R, Schmid-Grendelmeier P, Bieber T, Schäppi G, Traidl-Hoffmann C.
The role of environmental factors in allergy: A critical reappraisal. Exp Dermatol. 2018 Nov;27(11):1193-1200. doi: 10.1111/exd.13769.
Epub 2018 Sep 26. Review. PubMed PMID: 30099779.

13: Giannoni E, Agyeman PKA, Stocker M, Posfay-Barbe KM, Heininger U, Spycher BD, Bernhard-Stirnemann S, Niederer-Loher A, Kahlert CR, Donas A, Leone A, Hasters P, Relly C, Riedel T, Kuehni C, Aebi C, Berger C, Schlapbach LJ; Swiss Pediatric Sepsis Study.
Neonatal Sepsis of Early Onset, and Hospital-Acquired and Community-Acquired Late Onset: A Prospective Population-Based Cohort Study.
J Pediatr. 2018 Oct;201:106-114.e4. doi: 10.1016/j.jpeds.2018.05.048. Epub 2018 Jul 24. PubMed PMID: 30054165.

14: Kahlert C, Aebi-Popp K, Bernasconi E, Martinez de Tejada B, Nadal D, Paioni P, Rudin C, Staehelin C, Wagner N, Vernazza P.
Is breastfeeding an equipoise option in effectively treated HIV-infected mothers in a high-income setting?
Swiss Med Wkly. 2018 Jul 24;148:w14648. doi: 10.4414/smw.2018.14648. eCollection 2018. PubMed PMID: 30044473.

15: Rost M, Wangmo T, Rakic M, Acheson E, Rischewski J, Hengartner H, Kühne T, Elger BS.
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16: Kohler P, Fulchini R, Albrich WC, Egli A, Balmelli C, Harbarth S, Héquet D, Kahlert CR, Kuster SP, Petignat C, Schlegel M, Kronenberg A.
Antibiotic resistance in Swiss nursing homes: analysis of National Surveillance Data over an 11-year period between 2007 and 2017.
Antimicrob Resist Infect Control. 2018 Jul 20;7:88. doi: 10.1186/s13756-018-0378-1. eCollection 2018. PubMed PMID: 30038781;
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17: Gorlanova O, Illi S, Toncheva AA, Usemann J, Latzin P, Kabesch M, Dalphin JC, Lauener R, Pekkanen JR, Von Mutius E, Riedler J, Kuehni CE, Röösli M, Frey U;
BILD and PASTURE study groups. Protective effects of breastfeeding on respiratory symptoms in infants with 17q21 asthma risk variants.
Allergy. 2018 Dec;73(12):2388-2392. doi: 10.1111/all.13568. Epub 2018 Aug 9. PubMed PMID: 30030842.

18: Steppacher R, North D, Künzle C, Lengnick H, Klima H, Mündermann A, Wegener R.
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19: Castellani C, Duff AJA, Bell SC, Heijerman HGM, Munck A, Ratjen F, Sermet-Gaudelus I, Southern KW, Barben J, Flume PA, Hodková P, Kashirskaya N, Kirszenbaum MN, Madge S, Oxley H, Plant B, Schwarzenberg SJ, Smyth AR, Taccetti G, Wagner TOF, Wolfe SP, Drevinek P.
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20: Laimbacher J. Umfassende Behandlung von Adipositas im Kindes- und Jugendalter.
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21: Gerull R, Brauer V, Bassler D, Laubscher B, Pfister RE, Nelle M, Müller B, Gerth-Kahlert C, Adams M; Swiss Neonatal Network & Follow-up Group.
Incidence of retinopathy of prematurity (ROP) and ROP treatment in Switzerland 2006-2015: a population-based analysis.
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22: Delgado-Eckert E, Fuchs O, Kumar N, Pekkanen J, Dalphin JC, Riedler J, Lauener R, Kabesch M, Kupczyk M, Dahlen SE, Mutius EV, Frey U;
PASTURE and BIOAIR Study groups. Functional phenotypes determined by fluctuation-based clustering of lung function measurements in healthy and asthmatic cohort participants.
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23: Brunner TA, Casetti L, Haueter P, Müller P, Nydegger A, Spalinger J.
Nutrient intake of Swiss toddlers. Eur J Nutr. 2018 Oct;57(7):2489-2499. doi: 10.1007/s00394-017-1521-0. Epub 2017 Aug 10. PubMed PMID: 28812189.

24: Fulchini R, Kohler P, Kahlert CR, Albrich WC, Kuhn R, Hoffmann M, Schlegel M.
Hand hygiene adherence in relation to influenza season during 6 consecutive years. Am J Infect Control.
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Das Ostschweizer Kinderspital ist Mitgründer von SwissPedNet, einem Verbund Schweizer Kinderkliniken, welcher sich für Forschung im Bereich Kinder- und Jugendmedizin engagiert. Nähere Informationen finden Sie unter: www.swisspednet.ch

Team

Chefarzt Kinder- und Jugendmedizin

Prof. Dr. med. Roger Lauener

Mitglied der Spitalleitung, Facharzt für Kinder- und Jugendmedizin, Facharzt für Allergologie und Immunologie

Leiter Forschungskommission

Dr. med. Christian Kahlert

Facharzt für Kinder- und Jugendmedizin, Facharzt für Infektiologie

Studienkoordinatorin

Tanja Wachinger

M.Sc. Gesundheitswissenschaften, dipl. Pflegefachfrau